ISA Infrastructure - the format

Several examples of ISA-Tab v1.0 formatted metadata files are available in the table below. Other examples can be downloaded from the BioInvestigation Index public instance running at EBI.

Study Title	Example	Source	Creation process	Contributors
The influence of pharmacogenetics on fatty liver disease in the wistar and kyoto rats Assay Types: gene expression profiling using DNA microarray metabolite profiling using NMR spectroscopy		17203948	ISACreator/manual creation
Representation in ISA-TAB Format of an Investigations (mock-up), which includes a study by Gauguier et al, 2007 17618414, in addition to the study by Griffin et al,2007. Assay Types: gene expression profiling using DNA microarray metabolite profiling using NMR spectroscopy		17203948	ISACreator/manual creation
Metatranscriptomes of phytoplankton blooms from an ocean acidification mesocosm experiment Assay Types: gene expression profiling using DNA sequencing genomic sequence identification using DNA sequencing		18725995 SRA XML (SRA00026)	ISACreator/manual creation xsl transformation	Jack Gilbert and Dawn Field
Cell based assay study Assay Types: cell function profiling using cell assays		MIACA/ CA-ML	xsl transformation	file supplied by Stefan Wiemann, DKFZ, Acknowldgement to: Stephanie Bechtel and Christian Schmidt (data generation), Heiko Rosenfelder and David Zhang (bioinformatics).
FuGE exemplar document		FuGE-ML	xsl transformation	file supplied by Andy Jones for initial evaluation.
Microarray based study Assay Types: gene expression profiling using DNA sequencing		FuGE-ML	xsl transformation	file supplied by Allyson Lister, CISBAN SYMBA. Acknowldgement to: Amanda Greenall and David Lydall. .
Differential Gel Electrophoresis based study Assay Types: protein identification using gel electrophoresis		Gel-ML	xsl transformation	file supplied by Frank Gibson and Andy Jones.
Flow cytometry based study Assay Types: cell sorting using flow cytometry		FuGEFlow-ML	xsl transformation	file supplied by Joseph Splindlen. Acknowldgement to: Maura Gasparetto for providing the experimental description according to MIFlowCyt, Yu Qian, Olga Tchuvatkina, Josef Spidlen, Peter Wilkinson, Richard Scheuermann, Ryan Brinkman, for FuGEFlow Josef Spidlen for encoding the experimental description into FlowML. This is work was supported by the NIH under grant EB5034.